AustralieFrV1, Main, Exploration, bibRecord, 002840

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease.

Identifieur interne : 002840 ( Main/Exploration ); précédent : 002839; suivant : 002841

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease.

Auteurs : Jonas Persson ; Rona J. Strawbridge ; Olga Mcleod ; Karl Gertow ; Angela Silveira ; Damiano Baldassarre ; Natalie Van Zuydam ; Sonia Shah ; Cristiano Fava ; Stefan Gustafsson [Suède] ; Fabrizio Veglia ; Bengt Sennblad ; Malin Larsson ; Maria Sabater-Lleal ; Karin Leander ; Bruna Gigante ; Adam Tabak [Royaume-Uni] ; Mika Kivimaki [Royaume-Uni] ; Jussi Kauhanen ; Rainer Rauramaa ; Andries J. Smit ; Elmo Mannarino ; Philippe Giral ; Steve E. Humphries [Royaume-Uni] ; Elena Tremoli ; Ulf De Faire ; Lars Lind [Suède] ; Erik Ingelsson [Suède] ; Bo Hedblad ; Olle Melander ; Meena Kumari [Royaume-Uni] ; Aroon Hingorani [Royaume-Uni] ; Andrew D. Morris ; Colin N A. Palmer ; Pia Lundman ; John Öhrvik ; Stefan Söderberg ; Anders Hamsten

Source :

Journal of the American Heart Association [ 2047-9980 ] ; 2015.

RBID : pubmed:26276317

Descripteurs français

English descriptors

KwdEn :
- Adiponectin (blood), Adiponectin (genetics), Aged, Biomarkers (blood), Carotid Artery Diseases (blood), Carotid Artery Diseases (diagnostic imaging), Carotid Artery Diseases (epidemiology), Carotid Artery Diseases (genetics), Carotid Artery, Common (diagnostic imaging), Carotid Intima-Media Thickness, Disease Progression, Europe (epidemiology), Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Incidence, Male, Middle Aged, Polymorphism, Single Nucleotide, Predictive Value of Tests, Prognosis, Protective Factors, Risk Assessment, Risk Factors, Sex Factors, Time Factors.
MESH :
- chemical , blood : Adiponectin, Biomarkers.
- chemical , genetics : Adiponectin.
- blood : Carotid Artery Diseases.
- diagnostic imaging : Carotid Artery Diseases, Carotid Artery, Common.
- epidemiology : Carotid Artery Diseases, Europe.
- genetics : Carotid Artery Diseases.
- Aged, Carotid Intima-Media Thickness, Disease Progression, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Incidence, Male, Middle Aged, Polymorphism, Single Nucleotide, Predictive Value of Tests, Prognosis, Protective Factors, Risk Assessment, Risk Factors, Sex Factors, Time Factors.

Abstract

Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT.

DOI: 10.1161/JAHA.115.001853
PubMed: 26276317

Affiliations:

Le document en format XML

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<author><name sortKey="Persson, Jonas" sort="Persson, Jonas" uniqKey="Persson J" first="Jonas" last="Persson">Jonas Persson</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden (J.P., B.G., P.L.).</nlm:affiliation>
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<author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J" last="Strawbridge">Rona J. Strawbridge</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
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<author><name sortKey="Mcleod, Olga" sort="Mcleod, Olga" uniqKey="Mcleod O" first="Olga" last="Mcleod">Olga Mcleod</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
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<author><name sortKey="Gertow, Karl" sort="Gertow, Karl" uniqKey="Gertow K" first="Karl" last="Gertow">Karl Gertow</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
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<author><name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
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<author><name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name>
<affiliation><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy (D.B., E.T.) Centro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., F.V., E.T.).</nlm:affiliation>
<wicri:noCountry code="subField">E.T.).</wicri:noCountry>
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<author><name sortKey="Van Zuydam, Natalie" sort="Van Zuydam, Natalie" uniqKey="Van Zuydam N" first="Natalie" last="Van Zuydam">Natalie Van Zuydam</name>
<affiliation><nlm:affiliation>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.V.Z., A.D.M., C.A.P.).</nlm:affiliation>
<wicri:noCountry code="subField">C.A.P.).</wicri:noCountry>
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<author><name sortKey="Shah, Sonia" sort="Shah, Sonia" uniqKey="Shah S" first="Sonia" last="Shah">Sonia Shah</name>
<affiliation><nlm:affiliation>University College London Genetics Institute, University College London, London, United Kingdom (S.S.) Diamantina Institute and Queensland Brain Institute, University of Queensland, Australia (S.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Australia (S.S.).</wicri:noCountry>
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<author><name sortKey="Fava, Cristiano" sort="Fava, Cristiano" uniqKey="Fava C" first="Cristiano" last="Fava">Cristiano Fava</name>
<affiliation><nlm:affiliation>Division of Internal Medicine C, Department of Medicine, Hospital "Policlinico G.B Rossi", University of Verona, Italy (C.F.) Clinical Research Center, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden (C.F., B.H., O.M.).</nlm:affiliation>
<wicri:noCountry code="subField">O.M.).</wicri:noCountry>
</affiliation>
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<author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden (S.G., E.I.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
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<region nuts="1">East Middle Sweden</region>
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<author><name sortKey="Veglia, Fabrizio" sort="Veglia, Fabrizio" uniqKey="Veglia F" first="Fabrizio" last="Veglia">Fabrizio Veglia</name>
<affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., F.V., E.T.).</nlm:affiliation>
<wicri:noCountry code="subField">E.T.).</wicri:noCountry>
</affiliation>
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<author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.) Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden (B.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Sweden (B.S.).</wicri:noCountry>
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</author>
<author><name sortKey="Larsson, Malin" sort="Larsson, Malin" uniqKey="Larsson M" first="Malin" last="Larsson">Malin Larsson</name>
<affiliation><nlm:affiliation>IFM Bioinformatics, Linköping University, Linköping, Sweden (M.L.).</nlm:affiliation>
<wicri:noCountry code="subField">Sweden (M.L.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Leander, Karin" sort="Leander, Karin" uniqKey="Leander K" first="Karin" last="Leander">Karin Leander</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., B.G., U.F.).</nlm:affiliation>
<wicri:noCountry code="subField">U.F.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gigante, Bruna" sort="Gigante, Bruna" uniqKey="Gigante B" first="Bruna" last="Gigante">Bruna Gigante</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden (J.P., B.G., P.L.) Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., B.G., U.F.).</nlm:affiliation>
<wicri:noCountry code="subField">U.F.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tabak, Adam" sort="Tabak, Adam" uniqKey="Tabak A" first="Adam" last="Tabak">Adam Tabak</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom (A.T., M.K.) 1st Department of Medicine, Semmelweis University Faculty of Medicine, Semmelweis University, Budapest, Hungary (A.T.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom (A.T., M.K.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kauhanen, Jussi" sort="Kauhanen, Jussi" uniqKey="Kauhanen J" first="Jussi" last="Kauhanen">Jussi Kauhanen</name>
<affiliation><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (J.K.).</nlm:affiliation>
<wicri:noCountry code="subField">Finland (J.K.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name>
<affiliation><nlm:affiliation>Kuopio Research Institute of Exercise Medicine, Kuopio, Finland (R.R.) Department of Clinical Physiology and Nuclear Medicine, University Hospital of Kuopio, Kuopio, Finland (R.R.).</nlm:affiliation>
<wicri:noCountry code="subField">Finland (R.R.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Smit, Andries J" sort="Smit, Andries J" uniqKey="Smit A" first="Andries J" last="Smit">Andries J. Smit</name>
<affiliation><nlm:affiliation>Department of Medicine, University Medical Center Groningen, University of Groningen, The Netherlands (A.J.S.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (A.J.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mannarino, Elmo" sort="Mannarino, Elmo" uniqKey="Mannarino E" first="Elmo" last="Mannarino">Elmo Mannarino</name>
<affiliation><nlm:affiliation>Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Italy (E.M.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (E.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Giral, Philippe" sort="Giral, Philippe" uniqKey="Giral P" first="Philippe" last="Giral">Philippe Giral</name>
<affiliation><nlm:affiliation>Assistance Publique - Hopitaux de Paris, Service Endocrinologie-Metabolisme, Groupe Hôpitalier Pitie-Salpetriere, Unités de Prévention Cardiovasculaire, Paris, France (P.G.).</nlm:affiliation>
<wicri:noCountry code="subField">France (P.G.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, United Kingdom (S.E.H.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
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<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name>
<affiliation><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy (D.B., E.T.) Centro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., F.V., E.T.).</nlm:affiliation>
<wicri:noCountry code="subField">E.T.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., B.G., U.F.).</nlm:affiliation>
<wicri:noCountry code="subField">U.F.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden (L.L.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden (S.G., E.I.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name>
<affiliation><nlm:affiliation>Clinical Research Center, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden (C.F., B.H., O.M.).</nlm:affiliation>
<wicri:noCountry code="subField">O.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name>
<affiliation><nlm:affiliation>Clinical Research Center, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden (C.F., B.H., O.M.).</nlm:affiliation>
<wicri:noCountry code="subField">O.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name>
<affiliation wicri:level="4"><nlm:affiliation>Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, United Kingdom (M.K., A.H.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name>
<affiliation wicri:level="4"><nlm:affiliation>Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, United Kingdom (M.K., A.H.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D" last="Morris">Andrew D. Morris</name>
<affiliation><nlm:affiliation>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.V.Z., A.D.M., C.A.P.).</nlm:affiliation>
<wicri:noCountry code="subField">C.A.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Palmer, Colin N A" sort="Palmer, Colin N A" uniqKey="Palmer C" first="Colin N A" last="Palmer">Colin N A. Palmer</name>
<affiliation><nlm:affiliation>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.V.Z., A.D.M., C.A.P.).</nlm:affiliation>
<wicri:noCountry code="subField">C.A.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lundman, Pia" sort="Lundman, Pia" uniqKey="Lundman P" first="Pia" last="Lundman">Pia Lundman</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden (J.P., B.G., P.L.).</nlm:affiliation>
<wicri:noCountry code="subField">P.L.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ohrvik, John" sort="Ohrvik, John" uniqKey="Ohrvik J" first="John" last="Öhrvik">John Öhrvik</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Soderberg, Stefan" sort="Soderberg, Stefan" uniqKey="Soderberg S" first="Stefan" last="Söderberg">Stefan Söderberg</name>
<affiliation><nlm:affiliation>Division of Medicine, Department of Public Health and Clinical Medicine, University of Umeå, Sweden (S.).</nlm:affiliation>
<wicri:noCountry code="subField">Sweden (S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease.</title>
<author><name sortKey="Persson, Jonas" sort="Persson, Jonas" uniqKey="Persson J" first="Jonas" last="Persson">Jonas Persson</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden (J.P., B.G., P.L.).</nlm:affiliation>
<wicri:noCountry code="subField">P.L.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J" last="Strawbridge">Rona J. Strawbridge</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mcleod, Olga" sort="Mcleod, Olga" uniqKey="Mcleod O" first="Olga" last="Mcleod">Olga Mcleod</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gertow, Karl" sort="Gertow, Karl" uniqKey="Gertow K" first="Karl" last="Gertow">Karl Gertow</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name>
<affiliation><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy (D.B., E.T.) Centro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., F.V., E.T.).</nlm:affiliation>
<wicri:noCountry code="subField">E.T.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Van Zuydam, Natalie" sort="Van Zuydam, Natalie" uniqKey="Van Zuydam N" first="Natalie" last="Van Zuydam">Natalie Van Zuydam</name>
<affiliation><nlm:affiliation>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.V.Z., A.D.M., C.A.P.).</nlm:affiliation>
<wicri:noCountry code="subField">C.A.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shah, Sonia" sort="Shah, Sonia" uniqKey="Shah S" first="Sonia" last="Shah">Sonia Shah</name>
<affiliation><nlm:affiliation>University College London Genetics Institute, University College London, London, United Kingdom (S.S.) Diamantina Institute and Queensland Brain Institute, University of Queensland, Australia (S.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Australia (S.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Fava, Cristiano" sort="Fava, Cristiano" uniqKey="Fava C" first="Cristiano" last="Fava">Cristiano Fava</name>
<affiliation><nlm:affiliation>Division of Internal Medicine C, Department of Medicine, Hospital "Policlinico G.B Rossi", University of Verona, Italy (C.F.) Clinical Research Center, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden (C.F., B.H., O.M.).</nlm:affiliation>
<wicri:noCountry code="subField">O.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden (S.G., E.I.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Veglia, Fabrizio" sort="Veglia, Fabrizio" uniqKey="Veglia F" first="Fabrizio" last="Veglia">Fabrizio Veglia</name>
<affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., F.V., E.T.).</nlm:affiliation>
<wicri:noCountry code="subField">E.T.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.) Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden (B.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Sweden (B.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Larsson, Malin" sort="Larsson, Malin" uniqKey="Larsson M" first="Malin" last="Larsson">Malin Larsson</name>
<affiliation><nlm:affiliation>IFM Bioinformatics, Linköping University, Linköping, Sweden (M.L.).</nlm:affiliation>
<wicri:noCountry code="subField">Sweden (M.L.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Leander, Karin" sort="Leander, Karin" uniqKey="Leander K" first="Karin" last="Leander">Karin Leander</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., B.G., U.F.).</nlm:affiliation>
<wicri:noCountry code="subField">U.F.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gigante, Bruna" sort="Gigante, Bruna" uniqKey="Gigante B" first="Bruna" last="Gigante">Bruna Gigante</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden (J.P., B.G., P.L.) Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., B.G., U.F.).</nlm:affiliation>
<wicri:noCountry code="subField">U.F.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tabak, Adam" sort="Tabak, Adam" uniqKey="Tabak A" first="Adam" last="Tabak">Adam Tabak</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom (A.T., M.K.) 1st Department of Medicine, Semmelweis University Faculty of Medicine, Semmelweis University, Budapest, Hungary (A.T.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom (A.T., M.K.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kauhanen, Jussi" sort="Kauhanen, Jussi" uniqKey="Kauhanen J" first="Jussi" last="Kauhanen">Jussi Kauhanen</name>
<affiliation><nlm:affiliation>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (J.K.).</nlm:affiliation>
<wicri:noCountry code="subField">Finland (J.K.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rauramaa, Rainer" sort="Rauramaa, Rainer" uniqKey="Rauramaa R" first="Rainer" last="Rauramaa">Rainer Rauramaa</name>
<affiliation><nlm:affiliation>Kuopio Research Institute of Exercise Medicine, Kuopio, Finland (R.R.) Department of Clinical Physiology and Nuclear Medicine, University Hospital of Kuopio, Kuopio, Finland (R.R.).</nlm:affiliation>
<wicri:noCountry code="subField">Finland (R.R.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Smit, Andries J" sort="Smit, Andries J" uniqKey="Smit A" first="Andries J" last="Smit">Andries J. Smit</name>
<affiliation><nlm:affiliation>Department of Medicine, University Medical Center Groningen, University of Groningen, The Netherlands (A.J.S.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (A.J.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mannarino, Elmo" sort="Mannarino, Elmo" uniqKey="Mannarino E" first="Elmo" last="Mannarino">Elmo Mannarino</name>
<affiliation><nlm:affiliation>Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Italy (E.M.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (E.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Giral, Philippe" sort="Giral, Philippe" uniqKey="Giral P" first="Philippe" last="Giral">Philippe Giral</name>
<affiliation><nlm:affiliation>Assistance Publique - Hopitaux de Paris, Service Endocrinologie-Metabolisme, Groupe Hôpitalier Pitie-Salpetriere, Unités de Prévention Cardiovasculaire, Paris, France (P.G.).</nlm:affiliation>
<wicri:noCountry code="subField">France (P.G.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, United Kingdom (S.E.H.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name>
<affiliation><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy (D.B., E.T.) Centro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., F.V., E.T.).</nlm:affiliation>
<wicri:noCountry code="subField">E.T.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., B.G., U.F.).</nlm:affiliation>
<wicri:noCountry code="subField">U.F.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden (L.L.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden (S.G., E.I.).</nlm:affiliation>
<orgName type="university">Université d'Uppsala</orgName>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name>
<affiliation><nlm:affiliation>Clinical Research Center, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden (C.F., B.H., O.M.).</nlm:affiliation>
<wicri:noCountry code="subField">O.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name>
<affiliation><nlm:affiliation>Clinical Research Center, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden (C.F., B.H., O.M.).</nlm:affiliation>
<wicri:noCountry code="subField">O.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name>
<affiliation wicri:level="4"><nlm:affiliation>Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, United Kingdom (M.K., A.H.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hingorani, Aroon" sort="Hingorani, Aroon" uniqKey="Hingorani A" first="Aroon" last="Hingorani">Aroon Hingorani</name>
<affiliation wicri:level="4"><nlm:affiliation>Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, United Kingdom (M.K., A.H.).</nlm:affiliation>
<orgName type="university">University College de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D" last="Morris">Andrew D. Morris</name>
<affiliation><nlm:affiliation>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.V.Z., A.D.M., C.A.P.).</nlm:affiliation>
<wicri:noCountry code="subField">C.A.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Palmer, Colin N A" sort="Palmer, Colin N A" uniqKey="Palmer C" first="Colin N A" last="Palmer">Colin N A. Palmer</name>
<affiliation><nlm:affiliation>Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.V.Z., A.D.M., C.A.P.).</nlm:affiliation>
<wicri:noCountry code="subField">C.A.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lundman, Pia" sort="Lundman, Pia" uniqKey="Lundman P" first="Pia" last="Lundman">Pia Lundman</name>
<affiliation><nlm:affiliation>Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden (J.P., B.G., P.L.).</nlm:affiliation>
<wicri:noCountry code="subField">P.L.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ohrvik, John" sort="Ohrvik, John" uniqKey="Ohrvik J" first="John" last="Öhrvik">John Öhrvik</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Soderberg, Stefan" sort="Soderberg, Stefan" uniqKey="Soderberg S" first="Stefan" last="Söderberg">Stefan Söderberg</name>
<affiliation><nlm:affiliation>Division of Medicine, Department of Public Health and Clinical Medicine, University of Umeå, Sweden (S.).</nlm:affiliation>
<wicri:noCountry code="subField">Sweden (S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., O.M.L., K.G., A.S., B.S., M.S.L., J., A.H.).</nlm:affiliation>
<wicri:noCountry code="subField">A.H.).</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the American Heart Association</title>
<idno type="eISSN">2047-9980</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adiponectin (blood)</term>
<term>Adiponectin (genetics)</term>
<term>Aged</term>
<term>Biomarkers (blood)</term>
<term>Carotid Artery Diseases (blood)</term>
<term>Carotid Artery Diseases (diagnostic imaging)</term>
<term>Carotid Artery Diseases (epidemiology)</term>
<term>Carotid Artery Diseases (genetics)</term>
<term>Carotid Artery, Common (diagnostic imaging)</term>
<term>Carotid Intima-Media Thickness</term>
<term>Disease Progression</term>
<term>Europe (epidemiology)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Predictive Value of Tests</term>
<term>Prognosis</term>
<term>Protective Factors</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adiponectine (génétique)</term>
<term>Adiponectine (sang)</term>
<term>Adulte d'âge moyen</term>
<term>Artère carotide commune (imagerie diagnostique)</term>
<term>Artériopathies carotidiennes (génétique)</term>
<term>Artériopathies carotidiennes (imagerie diagnostique)</term>
<term>Artériopathies carotidiennes (sang)</term>
<term>Artériopathies carotidiennes (épidémiologie)</term>
<term>Europe (épidémiologie)</term>
<term>Facteurs de protection</term>
<term>Facteurs de risque</term>
<term>Facteurs sexuels</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Marqueurs biologiques (sang)</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Pronostic</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sujet âgé</term>
<term>Valeur prédictive des tests</term>
<term>Épaisseur intima-média carotidienne</term>
<term>Évaluation des risques</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adiponectin</term>
<term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adiponectin</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Carotid Artery Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Carotid Artery Diseases</term>
<term>Carotid Artery, Common</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Carotid Artery Diseases</term>
<term>Europe</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carotid Artery Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adiponectine</term>
<term>Artériopathies carotidiennes</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Artère carotide commune</term>
<term>Artériopathies carotidiennes</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Adiponectine</term>
<term>Artériopathies carotidiennes</term>
<term>Marqueurs biologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Artériopathies carotidiennes</term>
<term>Europe</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Carotid Intima-Media Thickness</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Predictive Value of Tests</term>
<term>Prognosis</term>
<term>Protective Factors</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs de protection</term>
<term>Facteurs de risque</term>
<term>Facteurs sexuels</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Pronostic</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sujet âgé</term>
<term>Valeur prédictive des tests</term>
<term>Épaisseur intima-média carotidienne</term>
<term>Évaluation des risques</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
<li>Suède</li>
</country>
<region><li>Angleterre</li>
<li>East Middle Sweden</li>
<li>Grand Londres</li>
<li>Svealand</li>
</region>
<settlement><li>Londres</li>
<li>Uppsala</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université d'Uppsala</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name>
<name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name>
<name sortKey="Fava, Cristiano" sort="Fava, Cristiano" uniqKey="Fava C" first="Cristiano" last="Fava">Cristiano Fava</name>
<name sortKey="Gertow, Karl" sort="Gertow, Karl" uniqKey="Gertow K" first="Karl" last="Gertow">Karl Gertow</name>
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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:26276317
   |texte=   Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease.
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Serveur d'exploration sur les relations entre la France et l'Australie

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease.

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease.

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	Serveur d'exploration sur les relations entre la France et l'Australie
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